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Immune Effector Cell Therapies

​​​​​​About Immune Effector Cell Therapy

Building on its extensive experience in stem cell transplantation, the program has served as a springboard for developing a comprehensive immune effector cell therapy program. CAR-T therapy, an approach that reengineers a patient’s immune cells to be able to recognize and attack cancer cells, is a new and important building block for the immune effector cell therapy program.

For the past 30 years, adoptive cellular therapy with immune effector cells including a variety of lymphocytes, have been developed at research centers around the world, including Baylor Dallas. Chimeric Antigen Receptor (CAR) T cells have emerged from the lab as FDA-approved treatments for a variety of cancers. This includes some gene-modified T cells and natural (NK) cells. The future for effector cell therapy is bright, as it becomes the treatment of choice for many cancer patients. Baylor Dallas will continue to play a leading role in these pioneering efforts.

Advancing Cancer Care with Personalized CAR-T

Baylor Charles A. Sammons Cancer Center at Dallas is the first center in North Texas to offer the first FDA approved chimeric antigen receptor (CAR) T cell therapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma (DLBCL), a type of non-Hodgkin’s lymphoma. CAR-T therapy allows a patient’s own immune system to help fight a disease. CAR-T clinical trials as well as other exciting immunotherapy applications are now available at Baylor Dallas. This important research has led to game-changing treatments that could improve the lives of cancer patients across Texas.

The Treatment

CAR-T is a personalized therapy in which:

  • a patient’s own immune cells are removed from his or her body
  • genetically reprogrammed
  • infused back into the patient to seek and destroy cancer cells.

Large numbers of the CAR-T cells for each individual patient are cultivated in the laboratory and given to the patient in a one-time infusion. The process from collection to infusion could take up to one month.

View our infographic​ to learn more about how CAR-T therapies work.

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