XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among peripheral artery disease (PAD) patients

The study will create a registry that will include entry of procedural and clinical follow-up information into an online data collection software, REDCap.



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XLPAD is a CMS-approved Qualified Clinical Data Registry (QCDR)

Objectives


  • Compare stent and non-stent based outcomes defined as a composite of symptom driven target vessel revascularization (TVR), unplanned surgical revascularization of the target limb and need for target limb amputation through 12 months post-index procedure (Primary efficacy endpoint)
  • Compare stent and non-stent based outcomes defined as a composite of causes such as: death, myocardial infarction (MI), stroke, peri-procedural complications, target vessel revascularization (TVR) and unplanned surgical revascularization/amputation of the target lib through 12 months (Primary safety endpoint)
  • Compare stent and non-stent based change in walking distance, Rutherford category and/or ankle-brachial index (ABI) at 12 months compared to baseline (Primary clinical improvement endpoint)

Research Electronic Data Capture (REDCap)

Online datasheet and database

To enter the XLPAD study, you first need to go to the Baylor Scott & White Research Institute REDCap website https://redcap.bswhealth.org/.

All data points will be entered through the online data entry form provided by the REDCap software.

The REDCap software provides a wide array of tools to conveniently analyze data, generate reports, import/export datasheets, and collaborate on data with your research team.

The data can be exported directly into an excel spreadsheet as well as into many of the most widely used statistical software packages such as SAS, SPSS, and STATA.

XLPAD manual

Download the XLPAD manual for information on how to access the REDCap registry.


Download manual

Investigators

Principal investigator


Subhash-Banerjee.jpeg

Subhash Banerjee, MD, FACC, FSCAI

Principal Investigator

View Dr. Banerjee's profile Dr. Banerjee's publications

Positions and Employment
  • 2022: Paul J. Thomas Endowed Chair, Chief of CV Research & Innovation Baylor Scott & White The Heart Hospital
  • 2014: Professor in Medicine, UT Southwestern Medical School
  • 2010: Associate Professor in Medicine, UT Southwestern Medical School
  • 2009: Chief, Division of Cardiology, VA North Texas Healthcare System
  • 2008: Adjunct Professor in Bioengineering, University of Texas at Arlington
  • 2004: Director, Cardiac Cath. Laboratory, Dallas VA Medical Center
  • 2004: Assistant Professor in Medicine, UT Southwestern Medical School

Honors and Awards
  • 2011: Cardiovascular Revascularization Leadership Award
  • 2010: Young Leadership Award in Cardiology Cardiovascular Revascularization Therapy
  • 2009: Cardiovascular Revascularization Leadership Award
  • 2007: VA North Texas Healthcare System Courtesy in Action Award
  • 2007: Emerging Cardiology Faculty Nomination American College of Cardiology
  • 2006: American College of Cardiology Emerging Faculty Nomination
  • 2003: Society for Cardiovascular Angiography and Interventions Honors
  • 2003: Peak Performance Award
  • 2003: Society for Cardiovascular Angiography and Interventions Honors
  • 2001: American Federation of Medical Research Travel Award
  • 2000: ACCF/Bristol Myers Squibb Affiliate Travel Award
  • 2000: Post-Doctoral Fellowship Award American Heart Association
  • 2000: American Heart Association Post-Doctoral Fellowship Award
  • 1999: Outstanding Teacher Award, NY Hospital. Queens, Cornell University
  • 1999: John Dwoek Teacher of the Year Award New York Hospital Medical Center. Queens Cornell University, NY
  • 1998: Best Resident Award, NY Hospital. Queens, Cornell University
  • 1997: Best Resident of the Year Award, NY Hospital. Queens, Cornell University
  • 1992: Doctor of Medicine with Honors Minsk Medical Institute, Minsk
  • 1992: Dean's List Minsk Medical Institute
  • 1992: Doctor of Medicine with Honors, Deans recognition for top student
  • 1986: Minsk medical Institute International Student Scholarship

Professional Associations and Affiliations
  • American College of Cardiology (FACC)t
  • American Heart Association
  • Society of Coronary Angiography and Interventions

Research Interests
  • Atherosclerotic Plaque Composition Imaging with Intravascular Ultrasound
  • Endothelial Progenitor Cell Mobilization
  • Peripheral Vascular Interventions
  • Saphenous Vein Graft Intervention

Sites

Active sites and investigators

  • Baylor Scott & White Research Institute, Dallas, TX - Subhash Banerjee, MD
  • VA North Texas Health Care System, Dallas, TX - Shirling Tsai, MD
  • Cleveland Clinic, Cleveland, OH - Arvinda Nanjundappa, MD
  • Wellmont CVA Heart Institute, Kingsport, TN - Gaurav Rana, MD
  • UC San Diego, San Diego, CA - Lawrence Ang, MD
  • Ascension Seton / UT Austin, Austin, TX - Peter Monteleone, MD
  • Detroit Medical Center (Wayne State), Detroit, MI - Chadi Alraies, MD
  • Case Western (Cleveland Medical Center HHVI), OH - Mehdi Shishehbor, DO, MPH, PhD

Contributing sites and investigators

  • CHRISTUS Health, Irving, TX - Srikant Damaraju, MD
  • Denver VA Medical Center, Denver, CO - Ehrin Armstrong, MD
  • Integris Hospital, Edmond, OK - George Chrysant, MD
  • Midwest Cardiovascular Research Foundation, Davenport, IA - Nicolas Shammas, MD
  • North Dallas Research Associates, McKinney, TX - Muhammad Khan, MD
  • Boston VA Medical Center, Boston, MA - Scott Kinlay, MD
  • Oklahoma University Health Sciences Center/VA Oklahoma Medical Center, Oklahoma, OK - Beau Hawkins, MD
  • UT Health Science Center, San Antonio, TX - Anand Prasad, MD
  • Emory University, Atlanta, GA - Kushrow A.K. Niazi, MD
  • Einstein Healthcare, Philadelphia, PA - Sahil Banka, MD
  • Carolina East Health System, New Bern, NC - David Jessup, MD
  • Tampa VA Medical Center, Tampa, FL - James Brooks, MD
  • East Tennessee State University, Johnson City, TN - Timir Paul, MD

Study executive committee

Subhash-Banerjee.jpeg

Subhash Banerjee, MD, FACC, FSCAI

Dr. Banerjee's publications

John Eidt

David Fernandez Vazque

David Fernandez Vazquez, MD

Dr. Vazquez's publications

Christopher Metzger

Christopher Metzger, MD

Dr. Metzger's publications

Aravinda Nanjundappa

Aravinda Nanjundappa, MD

Dr. Nanjundappa's publications

Zachary Rosol

Zachary Rosol, MD

Dr. Rosol's publications

Recent publications

  • Tsai S, Liu Y, Hoang L, et al. Comparative Outcomes of Interventions for Femoropopliteal Chronic Total Occlusion Versus Non-Chronic Total Occlusion Lesions From the Multicenter XLPAD Registry. J Am Heart Assoc. 2023;12(12):e028425. doi:10.1161/JAHA.122.028425
  • Soney H, Kakkilaya A, Vazquez DF, et al. Reproducibility of Femoropopliteal Artery Intravascular Ultrasound Imaging in Patients With Peripheral Artery Disease. Am J Cardiol. 2023;199:1-6. doi:10.1016/j.amjcard.2023.04.026
  • Meadors S, Klein A, Jeon-Slaughter H, et al. Short-Term Outcomes After Retrograde Versus Antegrade Crossing Approaches for Femoropopliteal Occlusive Disease. J Invasive Cardiol. 2023;35(1):E31-E36.
  • Vu MH, Sande-Docor GM, Liu Y, et al. Endovascular Treatment and Outcomes for Femoropopliteal In-Stent Restenosis: Insights from the XLPAD Registry. J Interv Cardiol. 2022;2022:5935039. Published 2022 Jul 15. doi:10.1155/2022/5935039
  • Kabir R, Vuppala S, Liu Y, et al. Clinical outcomes of patients with and without chronic kidney disease undergoing endovascular revascularization of infrainguinal peripheral artery disease: Insights from the XLPAD registry. Catheter Cardiovasc Interv. 2021;98(2):310-316. doi:10.1002/ccd.29491
  • Giannopoulos S, Jeon-Slaughter H, Kahlon RS, et al. Comparative 12-Month Outcomes of Drug-Coated Balloon Versus Non-Drug-Coated Balloon Revascularization Strategy in Chronic Limb-Threatening Ischemia: Results From the XLPAD Registry. Cardiovasc Revasc Med. 2020;21(10):1276-1284. doi:10.1016/j.carrev.2020.03.030
  • Armstrong EJ, Jeon-Slaughter H, Kahlon RS, Niazi KA, Shammas NW, Banerjee S. Comparative Outcomes of Supera Interwoven Nitinol vs Bare Nitinol Stents for the Treatment of Femoropopliteal Disease: Insights From the XLPAD Registry. J Endovasc Ther. 2020;27(1):60-65. doi:10.1177/1526602819885652
  • Banerjee S, Jeon-Slaughter H, Armstrong EJ, et al. Clinical Outcomes and Cost Comparisons of Stent and Non-Stent Interventions in Infrainguinal Peripheral Artery Disease: Insights From the Excellence in Peripheral Artery Disease (XLPAD) Registry. J Invasive Cardiol. 2019;31(1):1-9.
  • Khalili H, Jeon-Slaughter H, Armstrong EJ, et al. Atherectomy in below-the-knee endovascular interventions: One-year outcomes from the XLPAD registry. Catheter Cardiovasc Interv. 2019;93(3):488-493. doi:10.1002/ccd.27897

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