child playing a field after receiving treatment for Legg-Calve-Perthes disease

What is Legg-Calve-Perthes disease?

Legg-Calvé-Perthes disease, also called Perthes disease, is a rare condition that affects one or both hips. It develops in children, usually between the ages of 3 to 12. The condition temporarily cuts off the blood supply to the top of the thigh bone, also called the femoral head. This causes bone cells to weaken, making walking and running painful and difficult.

The word "disease" is still used, but Perthes is actually a process with different stages that can take several years. Most children with Perthes have a good long-term outlook. After 18 to 24 months of treatment, they can usually return to normal daily activities without major limitations.

Legg-Calve-Perthes disease symptoms

The first symptom most parents notice is a difference in the way their child walks and runs. In the condition’s early stages, your child may limp even if they don’t complain of pain. As the condition progresses, children may develop lower body pain that gets worse with activity.

This pain may cause your child to limp or have an unusual run. The change may be more obvious if your child plays sports or is engaged in other athletic activities.

Other signs and symptoms include:

  • Hip stiffness
  • Muscle spasms
  • One leg appears shorter than the other
  • Pain in the hip(s), knee, thigh or groin that worsens with activity
  • Thinning of the affected thigh muscle

Perthes disease mostly affects one hip. However, in about 10 to 12 percent of cases, both hips are affected, though usually not at the same time.

When to see a doctor 

Schedule an appointment with your child’s pediatrician if you notice your child repeatedly favoring one side when they walk or run or if they display other possible symptoms of Perthes disease. If needed, your pediatrician can refer your child to a hip specialist. The sooner treatment starts, the fewer complications your child may experience.

child suffering from Legg-Calve-Perthes disease playing with his father

What causes Legg-Calve-Perthes disease?

Your bones need a regular supply of blood to stay healthy. Blood delivers oxygen and nutrients that keep them strong. In children with Perthes disease, the blood supply to the femoral head is disrupted. The exact cause of this is unknown. Without enough oxygen and nutrients, the bone cells in the femoral head begin to die. Recent studies have found a possible connection between blood clotting disorders and Perthes disease.

Perthes disease risk factors

Perthes disease affects about 1 in 1,200 children, most between the ages of 3 and 12, but children can be as young as 2 when signs first appear. The condition is more common in children who come from lower socioeconomic backgrounds, and boys are four to five times more likely than girls to develop it.

How is Perthes disease diagnosed?

Children’s bones heal quickly and can often repair themselves. Early diagnosis and treatment of Legg-Calve-Perthes disease give the thighbone more time to reshape into a round form. Your child’s doctor will do a physical exam and review their medical history. They may order X-rays to look at the bones and use lab tests to rule out other possible causes.

  • Medical history and exam

    Your child’s medical history will help the doctor understand how long the symptoms have been present and how they have affected your child’s daily life. Their doctor needs to have a good idea of where the pain exists and whether it worsens with activity.

    The doctor will conduct a physical examination to help determine where the pain is located and how severe it is and note any other issues that are impacting your child’s daily movements. They will likely move your child’s legs into different positions to determine the hip’s range of motion. During the exam, your doctor will look for:

    • Leg length discrepancy (one leg that is longer than the other)
    • Loss of muscle in the thighs and buttocks from disuse
    • Loss of the ability to move the leg away from the body and toward the inside of the body
    • Pain on rotation in the front and toward the middle of the thigh or knee
  • Imaging and tests

    Imaging tests give your doctor a detailed view of your child’s hip bones, allowing them to see more clearly how far the condition has progressed and rule out other diagnoses. Blood tests give doctors more information about the underlying cause of the pain and bone deterioration and can help them determine whether Perthes or another condition is causing the pain.

    • Blood tests: Tests, such as a complete blood cell count and erythrocyte sedimentation rate (which can identify inflammation in the body), can help your doctor rule out other diagnoses.
    • Bone scan: A bone scan gives the doctor a detailed picture of the bones and organs and is another method of diagnosing Perthes disease, although this is used less commonly. Before the camera starts, a small amount of radioactive material is injected into the bloodstream, making the bones clearer in the images.
    • MRI scan: An MRI uses a magnet and radio waves to examine your child’s bones. It’s painless and can show the bones in greater detail if an X-ray is insufficient for a diagnosis.
    • X-rays: X-rays use electromagnetic radiation to take pictures of the inside of the body.

Perthes disease treatment 

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Treatment of Perthes disease aims to manage your child’s pain and discomfort, help restore range of motion in the hips, and ensure a secure, permanent fit of the ball of the hip joint into the socket once it’s fully re-formed.

If your child is younger than 6 years old, they may only require nonsurgical treatment options. Treatment options also depend on how much damage the ball and socket joint has sustained and where your child is in the condition’s process.

Lifestyle changes

Your child’s activity levels will be limited if it’s suspected they have Perthes disease or if they’re diagnosed with the condition. It’s important to minimize their discomfort and allow the bone to regrow properly. This may include bed rest, a wheelchair, non-weight-bearing, gently moving the legs with weights, and the use of a walker or crutches while your child’s bones heal.

Medication

Medication for Perthes disease aims to minimize your child’s pain by decreasing the inflammation of their joint(s).

Your child may be prescribed nonsteroidal anti-inflammatory drugs, or NSAIDs, including ibuprofen and naproxen. Your doctor will explain the dosing schedule to you, and it may change as your child's condition is treated.

Physical therapy

Physical therapy is often the first treatment for children with mild symptoms of Perthes disease and typically begins shortly after diagnosis. It helps restore hip joint range of motion, reduce pain and inflammation, and protect the joint during healing.

A physical therapy program may include exercises to:

  • Improve hip range of motion
  • Strengthen muscles in the pelvis and legs
  • Address balance and walking difficulties
  • Prevent stiffness in muscles and joints

Casting and bracing

Sometimes, healthcare providers may recommend using a removable Petrie cast to keep the ball of the hip joint positioned correctly in the socket while it heals in very young people. This rigid, fiberglass cast covers both legs from the hips to the ankles and has a bar connecting the legs to keep them spread apart in the shape of the letter “A.” The cast can be removed temporarily for physical therapy.

Your child will usually wear the cast full-time for up to six months. Afterward, it is typically worn only at night.

Surgery

Surgery is sometimes recommended for children with Perthes disease who are older or have a significant deformity. Two common procedures used to treat Perthes disease include:

  • Osteotomy: Your child’s femur or pelvic bone is cut to fit securely within the hip socket, repositioning the bone correctly so it can regrow in the right place. Plates and screws secure the area as it heals. These are removed once treatment is complete.
  • Hip arthroscopy: This less invasive procedure may be used to treat complications related to Perthes disease, such as hip impingement. In arthroscopy, a surgeon inserts a camera and small surgical instruments through tiny incisions.

Locations

If your child is living with Perthes Disease, we offer several locations for their care, including specialty orthopedic centers in North and Central Texas.

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Frequently asked questions

  • Is Perthes disease hereditary?

    Perthes disease may have a genetic component in a small number of cases. About 10% of children with Perthes disease have a relative who was also diagnosed with the condition. However, doctors generally consider Perthes disease to be "idiopathic," meaning its exact cause is unknown.

  • How rare is Perthes disease?

    Perthes disease is rare, affecting less than 1% of the general population. However, it is four times more common in boys than in girls. Despite its rarity, it is important to recognize the condition for early diagnosis and treatment.

  • Can Perthes disease affect adults?

    Perthes disease mainly affects children, but it can cause hip pain and problems in adults who had the disease as children. The femoral head may become misshapen, leading to osteoarthritis later in life. So, even if the symptoms disappear during childhood, hip problems can appear as an adult.

  • Does Perthes disease affect growth?

    Yes, Perthes disease can affect a child’s growth. It may cause a leg length difference due to the femoral head deforming in the hip joint during growth. Younger children, with more growth potential, often have a better chance of remodeling and reducing the impact on leg length.