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Immunotherapy

Baylor Scott & White Charles A. Sammons Cancer Center – Dallas

  • Cancer Hates Fighters

    We provide patients with a wide array of novel therapeutics to defeat cancer — including immunotherapies that re-engineer your existing immune cells, giving your body the power to fight cancer from the inside. It’s no wonder cancer hates us, and we intend to keep it that way.

  • Cancer Hates Innovators

    Traditionally there are three approaches to treating cancer – surgery, radiation and chemotherapy. Now through clinical research breakthroughs, we have the fourth pillar in cancer care -- immunotherapy. We can now utilize your immune cells to fight cancer at the microscope level.

A destination center for immunotherapy in North Texas

When it comes to immunotherapy for cancer, few hospitals offer what we do—all in one convenient location. Baylor University Medical Center, part of Baylor Scott & White Health, represents one of the largest cancer treatment centers in Texas and is the only medical center in North Texas that both manufactures novel immunotherapy cancer treatments and delivers them to you on the same campus.

The therapies produced at Baylor Scott & White Research Institute’s Good Manufacturing Practice Core lab (cGMP) for immunotherapy treatment on our campus—combined with our dedicated cancer hospital, outpatient cancer center, cancer urgent care and onsite overnight accommodations free-of-charge at the American Cancer Society’s Hope Lodge (opening Spring 2021) and numerous support services—provide a single destination to care for you as a whole person.

And we continue to research and advance numerous other immunotherapies every day. For fighters like you, this means access to clinical trials you won’t find elsewhere and even more hope to destroy cancer.

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  • Navigate your options

    Our patient navigators help connect you with personalized cancer care, including advanced options like immunotherapy.

Fight cancer with your own immune cells

Cancer treatment has typically included three main approaches—chemotherapy, radiation and surgery. Now, immunotherapy gives you a fourth tool to defeat cancer.

Through cellular therapies, we take your own immune cells, reprogram and multiply them in our lab, and infuse them back into your blood as new cancer-attacking cells. Other therapies use specific proteins or drugs to boost your immune system and help it fight cancer better.

Our clinical team is skilled in the research and administration of immunotherapy for cancer, and is committed to bringing novel therapies to the clinical setting. Baylor University Medical Center was the first North Texas hospital to offer FDA-approved chimeric antigen receptor T cell.

LEARN HOW IMMUNOTHERAPY WORKS

Depending on your cancer, some immunotherapies include:

CAR-T therapy
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CAR-T therapy uses modified T cells, a type of immune cell, to fight cancer. After taking T cells from your blood, a synthetic receptor called a chimeric antigen receptor (CAR) is added to your T cells in the lab, and the cells are multiplied. These new CAR-T cells are then infused back into your body to target specific antigens on the surface of cancer cells.
T cell receptor (TCR) therapy
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Similar to CAR-T therapy, T cell receptor (TCR) therapy modifies a person’s own T cells in the lab with a receptor that can target specific cancer cells. These modified cells are multiplied and infused back in the person to attack cancer. TCR is different from CAR-T in the type of antigens the T cells target.
Natural killer (NK) cell therapy
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A natural killer (NK) cell is a type of immune cell that looks for many types of abnormal cells in the body and attacks them. In the lab, NK cells can be multiplied or modified and then infused into a person to help the body better attack cancer cells. Unlike T cell therapies, NK cell therapy doesn’t require the use of an individual’s own cells.
Therapeutic vaccines
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The cGMP lab on the Dallas campus is involved in manufacturing dendritic cell vaccines for various types of cancer. When modified in the lab and delivered as a vaccine, immature dendritic cells, a type of immune cell, can help prompt the immune system to target cancer cells as invaders.
Monoclonal antibodies
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Antibodies are proteins made by your immune system that stick to specific foreign cells to help your body destroy them. Monoclonal antibodies are manufactured antibodies that act like natural antibodies. There are a few different types of monoclonal antibodies, but they are all designed to help your immune system find and attack cancer better.
Immune checkpoint inhibitors
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Your body has immune checkpoints to help keep your T cells from destroying healthy cells. However, when immune checkpoints are present on cancer cells, it can shut off T cells so that they don’t attack the cancer. Immune checkpoint inhibitors block these checkpoints on cancer cells, allowing T cells to recognize and destroy them.
Tumor-infiltrating cells
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Tumor-infiltrating lymphocytes are immune cells that go from your blood into a tumor to kill cancer cells. These lymphocytes can be taken from a person’s tumor and multiplied in the lab. This larger number of lymphocytes is then infused back into the person to boost the immune system’s ability to destroy cancer.

cGMP lab

Manufacturing innovative immunotherapies

Our cGMP lab has been manufacturing human cellular products since 2005. In that time, we’ve been involved in the manufacture, testing and release of products for numerous clinical trials, including those for melanoma, pancreatic cancer, multiple myeloma and more.

As a certified facility, every aspect of our cGMP lab is designed to maximize product consistency and quality. In the lab, we culture, split, harvest, consolidate and concentrate cells in a sterile environment. For your safety, we use a number of tests and quality checks before we hand-deliver these remanufactured cells back to the hospital for your care.

Located on our hospital campus here in Dallas, the cGMP lab helps us bring research and clinical care together in one collaborative team. It also provides access to these innovative cancer therapies closer to you—creating a quick, smooth treatment experience.

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Texas Immuno-Oncology Biorepository (TIOB)

The Texas Immuno-Oncology Biorepository (TIOB) is a research facility that collects, catalogs and stores samples of biological material, such as urine, blood, stool, tissue, cells, DNA, RNA and protein, in an effort to improve our understanding of cancer.

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